[Work Log] FIRE meeting notes
The following is an unedited set of notes from Friday's meeting.
multiplexes
il-6 and Il-1 correlated with XXX. Highest confidence
TNF-\alpha bad correlation with XXX - will it stand up? lower confidence
- Thad - harder to correlated with mind/body stimuli
IFN \gamma - mostly out of range (low levels)
Plates:
- some variability between plates.
- same person always had same plate.
- for each plate, we know what was the smallest readable value.
- should we replace OOR< with plate minimum?
- could we model it as a bound?
properly report how immune markers correlate in our data?
- Rebecca has ICC values.
Karen
- IL-6 tends to increase as disease progresses
- shouldn't occur in our subjects, because disease isn't progressing.
- Some people had cancer return (12 died), so it might apply there.
- IL-6 and TNF-alpha seem to be linked to mortality in breast cancer.
Absolute inflamatory markers aren't clinically calibrated, but covariation may be explanatory.
Th2 Th2? Immune activation. ratio of Th1 and Th2 molecules.
- see early part of karen's paper.
Thad: Women being treated for health cancer are relatively healthy for 50
- most studies are in the context of extreme stress and .
- radion and chemo may be
- we see IL-6, etc firing in the first or second visit after in these events.
- hypothesis: high levels of markers could maybe lead to psychological issues later.
- fatigue / depression relationship
- turning on inflamatory stuff doesn't really help things. Sometimes cancer thrives on it.
- turning down inflamation before treatment can result in more effective radiotion treatment (karen: this is questionable)
Can I get info on chemo treatment?
What variables do we care most about?
- time
- treatments
- other biological?
- have a partner?
CENTER ON TREATMENT
TNF alpha, IL-1, and IL-6 (in that order) you'd expect to see during cancer treatment
- how long before observation did most recent treatment occur?
Radiation duration: 1 month (sampling point could come before or during)
have chemo dates, but not radiation dates.
- use "days since treatment" for chemo.
- Karen: we should have radiation dates too, double check.